Outcomes and factors by risk group after prostate brachytherapy: Cohort study in 2316 patients


  • Norihisa Katayama Dept. of Radiology, Okayama University Medical School
  • Katsumasa Nakamura Department of Radiation Oncology, Hamamatsu University School of Medicine
  • Atsunori Yorozu Department of Radiation Oncology, National Hospital Organization Tokyo Medical Center
  • Takashi Kikuchi Translational Research Informatics Center
  • Taiki Magome Department of Radiological Sciences, Faculty of Health Sciences, Komazawa University
  • Shiro Saito Department of Urology, National Hospital Organization Tokyo Medical Center

Palabras clave:

poster, seram, comunicación oral, Outcomes, and, factors, by, risk, group, after, prostate, brachytherapy:, Cohort, study, in, 2316, patients


PURPOSE: To evaluate bFFF by risk group and treatment modality and the predictive factors of bFFF by risk group in patients with prostate cancer undergoing permanent seed implantation (PI) ± external beam radiation therapy (EBRT) in a nationwide prospective cohort study in Japan (J-POPS) during the first 2 years. METHODS AND MATERIALS: The analyses included 2,316 participants. BFFF was evaluated using the Phoenix definition. The Cox proportional hazards model was used to identify the factors associated with bFFF. RESULTS: Median follow-up period was 60.0 months. The 5-year bFFF rates in all patients, 1,028 low-risk patients, 1,114 intermediate-risk patients, and 133 high-risk patients were 93.6%, 94.9%, 92.7%, and 91.1%, respectively. The 5-year bFFF rates in the PI group and EBRT combination therapy group were 93.7% and 93.3%, respectively. In a multivariate analysis, younger age, higher Gleason score (GS), higher percent positive biopsies (%PB), and lower prostate V100 (p=0.0012, 0.0030, 0.0026, and 0.0368) in all patients; younger age, higher pretreatment prostate-specific antigen (PSA), and lower prostate V100 (p=0.0002, 0.0048, and 0.0012) in low-risk patients; higher GS, higher %PB, and no hormonal treatment (p=0.0005, 0.0120, and 0.0022) in intermediate-risk patients; and higher GS and higher %PB (p=0.0329 and 0.0120) in high-risk patients were significantly associated with bFFF. CONCLUSIONS: PI ± EBRT resulted in excellent short-term biochemical outcomes in all risk groups, especially in high-risk patients. Age, pretreatment PSA, and prostate V100 in low-risk patients; GS, %PB, and hormonal treatment in intermediate-risk patients; and GS and %PB in high-risk patients were independently affected bFFF.


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Cómo citar

Katayama , . N., Nakamura , . K., Yorozu , . A., Kikuchi , . T., Magome , . T., & Saito , . S. (2021). Outcomes and factors by risk group after prostate brachytherapy: Cohort study in 2316 patients. Seram, 1(1). Recuperado a partir de https://piper.espacio-seram.com/index.php/seram/article/view/4721