Valoración del grosor del complejo íntima-media carotídeo con ultrasonidos en niños obesos
Palabras clave:
grosor del complejo íntima-media carotídeo, poster, seram, niños obesos, ultrasonidos, GIM carotídeo, Programa SALUD 5-10Resumen
Objetivos
1.Establecer un protocolo de examen con US de la medida del GIM carotídeo que sea reproducible y seguro.
2.Verificar la reproducibilidad interobservador en la medida del GIM carotídeo mediante ecografía.
3.Describir el diseño y metodología utilizada en el Programa SALUD 5-10, programa de ejercicio físico diseñado con el objetivo de abordar el sobrepeso y obesidad en escolares de una franja de edad entre 5 a 10 años, mejorando su condición física y salud cardiovascular.
4.Evaluar el GIM mediante US en niños con sobrepeso y obesidad entre 5 y 10 años.
5.Evaluar la enfermedad grasa no alcohólica del hígado mediante US en niños con sobrepeso y obesidad entre 5 y 10 años.
6.Valorar la asociación entre el GIM y la enfermedad grasa no alcohólica del hígado en niños con sobrepeso y obesidad entre 5 y 10 años.
7.Verificar la reversibilidad del GIM y la disfunción endotelial después de la realización de un programa de ejercicio físico.
8.Verificar la reversibilidad de la enfermedad grasa no alcohólica del hígado después de la realización de un programa de ejercicio físico.
Material y métodos
El presente estudio es parte del programa de salud “SALUD 5-10 “, programa de ejercicio físico diseñado con el objetivo de abordar el sobrepeso y obesidad en escolares de una franja de edad entre 5 a 10 años, mejorando su condición física y salud cardiovascular.
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A. de Arriba Muñoz, M.M. Domínguez Cajal, J.I. Labarta Aizpún et al., “Carotid intimamedia thickness; normal values from 4 years”, . Nutricion Hospitalaria, vol. 28, no. 4, pp. 1171-1176, 2013. 14
A. Sartorio, A. Del Col, F. Agosti et al., “Predictors of non-alcoholic fatty liver disease in obese children”, European Journal of Clinical Nutrition, vol. 61, no. 7, pp. 877-883, 2007
Baldasarre D, Amato D, Bondioli A, Sirtori CR, Tremoli E. Carotid artery intima-media thickness measured by ultrasonography in normal clinical practice correlates well with atherosclerosis risk factors. Circulation 2000;31:2426-2430.
Bots M, Evans G, Riley W, Grobbee D. Carotid intima-media thickness measurements in intervention studies. Design options, progression rates and sample size considerations: a point of view. Stroke 2003;23:2985-2994.
Callister TQ, Raggi P, Cooil B, Lippolis NJ, Russo DJ. Effect of HMG-CoA reductase inhibitors on coronary artery disease as assessed by electron-beam computed tomography. N Engl J Med 1998;339:1972-1978.
Cañete R, Gil-Campos M, Aguilera CM, Gil A. Development of insulin resistance and its relation to diet in the obese child. Eur J Nutr. 2007; 46: 181-7.
Cruz ML, Weigensberg MJ, Huang TT, Ball G, Shaibi GQ, Goran MI. The metabolic syndrome in overweight Hispanic youth and the role of insulin sensitivity. J Clin Endocrinol Metab. 2004; 89: 108-13.
D.S. Freedman, D.A. Patel, S.R. Srinivasan et al., “The contribution of childhood obesity to adult carotid intima-media thickness: the Bogalusa Heart Study”, International Journal of Obesity (Lond) 2008;32(5):749-756.
Dalmau J, Alonso M, Gómez L, Martínez C, Sierra C. Obesidad Infantil. Recomendaciones del Comité de Nutrición de la Asociación Española de Pediatría. Parte II. Diagnóstico. Comorbilidades. Tratamiento. An Pediatr (Barc). 2007; 66: 294-304.
Daniel A. Hackett, Jacob George, Nathan A. Johnson Exercise and non-alcoholic fatty liver disease: A systematic review and meta-analysis. Journal of Hepatology 2012; 57 (1): 157-166.
F. Guzmán-Aroca, MD Frutos-Bernal, A. Bas, J. A. Luján-Mompeán, M. Reus, Juan de Dios Berná-Serna and P. Parrilla, Detection of non-alcoholic steatohepatitis in patients with morbid obesity before bariatric surgery: preliminary evaluation with acoustic radiation force impulse imaging, European Radiology, 2012; 22 (11): 2525-32
F. Velázquez F, J.D. Berná, J.L. Abellán, L. Serrano, A. Escribano and M. Canteras, “Reproducibility of sonographic measurements of carotid intima-media thickness”, Acta Radiologica, vol. 49, no. 10, pp. 1162-1166, 2008.
Falagas ME y Kompoti M. Obesity and infection. Lancet Infect Dis. 2006; 6: 438-46. Farpour-Lambert, N.J., et al., Physical activity reduces systemic blood pressure and improves early markers of atherosclerosis in pre-pubertal obese children. J Am Coll Cardiol, 2009. 54(25): 2396-406.
Garaulet M y Pérez de Heredia F. Behavioural therapy in the treatment of obesity (II): role of the Mediterranean diet. Nutr Hosp. 2010; 25: 9-17.
Gerrity RG. The role of monocyte in atherogenesis, II: migration of foam cells from atherosclerotic lesions. Am J Pathol. 1981;103:191-200.
Gil-Campos M, Aguilera CM, Cañete R, Gil A. Uric acid is associated with features of insulin resistance syndrome in obese children at prepubertal stage. Nutr Hosp. 2009; 24: 611-7.
Lorenz M, von Kegler S, Steinmetz H, Markus H, Sitzer M. Carotid intima-media thickening indicates a higher vascular risk across a wide age range. Prospective data from the Carotid Atherosclerosis Progression study (CAPS). Stroke 2006;37:87-92.
Lusis AJ. Atherosclerosis. Nature. 2000; 407: 233-41. M. Juonala, C.G. Magnussen, G.S. Berenson et al., “Childhood adiposity, adult adiposity, and cardiovascular risk factors”, New England Journal of Medicine, vol. 365, no. 20, pp. 1876-1885, 2011. 12
Mukherjee D, Yadav JS. Carotid artery intimal-medial thickness: indicator of atherosclerotic burden and response to risk factor modification. Am Heart J 2002;144: 753-9.
Muñoz M, Mazure RA y Culebras JM.Obesidad y sistema inmune. Nutr Hosp. 2004; 19: 319-24.
Nagal Y, Matsumoto M, Metter EJ. The carotid artery as a non-invasive window for cardiovascular risk in apparently healthy individuals. Ultrasound Med Biol 2002;28:1231-1238.
O’Leary DH, Polak JF. Intima-media thickness: a tool for atherosclerosis imaging and event prediction. Am J Cardiol 2002;990 (supl.10C):18L-21L.
O’Rourke RA, Brundage BH, Froelicher VG. American College of Cardiology. American Heart Association Expert Consensus Document on electron-beam computed tomography for the diagnosis and prognosis of coronary artery disease. Circulation 2000;102:126-40.
Oei HH, Vliegenthart R, Hak AE, Iglesias del Sol A, Hofman A, Oudkerk M, et al. The association between coronary calcification assessed by electron beam computed tomography and measures of extracoronary atherosclerosis. The Rotterdam Coronary Calcification Study. J Am Coll Cardiol 2002;39:1745-1751.
Serra Majem L, Ribas Barba L, Aranceta Bartrina J, Pérez Rodrigo C, Saavedra Santana P. Epidemiología de la obesidad infantil en España. Resultados del estudio enKid (1998-200). Ed Masson, 2001: 81-108.
Shiroma, E.J. and I.M. Lee, Physical activity and cardiovascular health: lessons learned from epidemiological studies across age, gender, and race/ethnicity. Circulation, 2010. 122(7):743-52.
Simionescu N, Heltianu C, Antohe F, et al. Endothelial cell receptors for histamine. Ann N Y Acad Sci. 1982;401:132-49.
Simon A, Gariepy J, Chironi C, Megnien JL, Levenson J. Intima-media thickness : a new tool for diagnosis and treatment of cardiovascular risk. J Hypertens 2002;20:159-169.
Stary HC, Chandler AB, Dinsmore RE, et al. A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Arterioscler Thromb Vasc Biol. 1995;15:1512-31.
Statistics Canada. Directly measured physical activity of Canadian children and youth, 2007 to 2011. 2013; Available from: http://www.statcan.gc.ca/pub/82-625-
x/2013001/article/11817-eng.pdf.
Stensland-Bugge E, Bonaa K, Joakimsen O. Age and sex differences in the relationship between inherited and lifestyle risk factors and subclinical carotid atherosclerosis: the Tromso study. Atherosclerosis 2001;154:437-448.
Van Kruijsdijk RC, van der Wall E, Visseren FL. Obesity and cancer: the role of dysfunctional adipose tissue. Cancer Epidemiol Biomarkers Prev. 2009; 18: 2569-78.
Vanhees, L., et al., How to assess physical activity? How to assess physical fitness? Eur J Cardiovasc Prev Rehabil, 2005. 12(2): 102-14.
Vinner RM, Segal TY, Lichtarowicz- Krynska E, hidmarsh P. Prevalence of the insulin resistance syndrome in obesity. Arch Dis Child. 2005; 90: 10- 4.
Wang Y. Is obesity associated with early sexual maturation? A comparation of the association in American boys versus girls. Pediatrics. 2002; 110: 903-10.
Warren, J.M., et al., Assessment of physical activity - a review of methodologies with reference to epidemiological research: a report of the exercise physiology section of the European Association of Cardiovascular Prevention and Rehabilitation. Eur J Cardiovasc Prev Rehabil, 2010. 17(2): 127-39.
Yuan C, Zhao XQ, Hatsukami TS. Quantitative evaluation of carotid atherosclerotic plaques by magnetic resonance imaging. Curr Atheroscler Rep 2002;4:351-357.
Zelber-Sagi S, Ratziu V, Zvibel I, Goldiner I, Blendis L, Morali G et al. The association between adipocytokines and biomarkers for nonalcoholic fatty liver disease-induced liver injury: a study in the general population. Eur J Gastroenterol Hepatol. 2012;24:262-9.
Zhao XQ, Yuan C, Hatsukami TS, Frechette EH, Kang XJ, Maravilla KR, et al. Effects of prolonged intensive lipid-lowering therapy on the characteristics of carotid atherosclerotic plaques in vivo by MRI. A case-control study. Arterioscler Thromb Vasc Biol 2001;21:1623-1629.
